PubMed Google Scholar. Increased bilirubin, increased serum creatinine, jaundice, leukopenia. Susceptibility testing is recommended in patients who fail therapy; if resistance to this drug is established, a non-clarithromycin-containing regimen is recommended. Dialysis Data not available Comments: Serum levels not expected to be significantly affected by hemodialysis or peritoneal dialysis. Intranasal interleukin-12 therapy inhibits Mycoplasma pneumoniae clearance and sustains airway obstruction in murine pneumonia.
Gonzalo JA, Lloyd CM, Wen D,. CrCl less than 30 mL/min: Clarithromycin dose should be reduced. Uses: For the treatment of acute maxillary sinusitis due to Haemophilus influenzae, Moraxella catarrhalis, or S pneumoniae. Antimicrobial and immunologic activities of clarithromycin in a murine model of Mycoplasma pneumoniae -induced pneumonia. Microbiologic and immunologic evaluation of a single high dose of azithromycin for treatment of experimental Mycoplasma pneumoniae pneumonia. Uses: For the treatment of uncomplicated skin and skin structure infections due to S aureus or S pyogenes Usual Pediatric Dose for Mycobacterium avium-intracellulare - Prophylaxis Immediate-release : how to Manage Asthma in the Winter and Stay out of the ER 20 months or older:.5 mg/kg orally twice a day Maximum.
Liver Dose Adjustments No adjustment recommended. Usual Pediatric Dose for Tonsillitis/Pharyngitis Immediate-release : 6 months or older:.5 mg/kg orally every flu is on the Rise in 2019: Know When to Go to the ER 12 hours for 10 days Maximum dose: 500 mg/dose Uses: For the treatment of pharyngitis/tonsillitis due to S pyogenes Usual Pediatric Dose for Sinusitis. Comments: Decreased dose or prolonged dosing intervals may be appropriate. McCracken., Jr Current status of antibiotic treatment for.
Clarithromycin Dosage Guide with Precautions
PubMed, google Scholar. The macrolide antibiotics: a pharmacokinetic and pharmacodynamic overview. PMC free article PubMed Google Scholar. Regimens containing this drug should not be used in patients with known or suspected clarithromycin-resistant isolates; efficacy of therapy is reduced. Treatment of experimental chronic pulmonary mycoplasmosis. Li X, Atkinson TP, Hagood J,.
Chronic suppressive therapy (secondary prophylaxis) is recommended after initial therapy. Cardiac disorders: Torsades de pointes, ventricular tachycardia, ventricular arrhythmia. Ros AM, Fonseca-Aten M, Mejas A,. Safety and efficacy of the extended-release formulation in treating other infections for which the immediate-release formulations are approved have not been established. Tigecycline therapy significantly reduces the concentrations of inflammatory pulmonary cytokines and chemokines in a murine model of Mycoplasma pneumoniae pneumonia. Van Schaik SM, Enhorning G, Vargas I,.
Textbook of Pediatric Infectious Diseases. Matsubara K, Morozumi M, Okada T,. Uses: For the treatment of uncomplicated skin and skin structure infections due to Staphylococcus aureus or S pyogenes. Combination therapy with at least 2 antimycobacterial drugs is recommended to prevent/delay resistance development. Shake the oral solution well before each use. Schwarze J, Hamelmann E, Bradley KL,.
Clarithromycin dosing, indications, interactions, adverse
This drug should be used with ethambutol for chronic maintenance therapy; same regimen as for treatment. Usual Pediatric Dose for Mycobacterium avium-intracellulare - Treatment Immediate-release : 20 months or older:.5 mg/kg orally twice a day Maximum dose: 500 mg/dose Comments : -Recommended as the primary agent for the treatment of disseminated infection. Nilsson AC, Björkman P, Persson. Usual Pediatric Dose for Pertussis US CDC recommendations : Immediate-release : 1 month or older:.5 mg/kg orally every 12 hours for 7 days Maximum dose: 500 mg/dose Comments : -Recommended for treatment and postexposure prophylaxis -Macrolides are preferred agents for the treatment of pertussis. Use: For the treatment of community-acquired pneumonia due to Mycoplasma pneumoniae. The manufacturer product information for the other drugs indicated in combination with clarithromycin should be consulted.
The impact of steroids given with macrolide therapy on experimental Mycoplasma pneumoniae respiratory infection. Comments : -Abscesses usually require surgical drainage. Am J Respir Cell Mol Biol. Some experts recommend stopping chronic suppressive therapy in patients 2 years or older who have completed at least 12 months of MAC therapy, who have no signs/symptoms of MAC disease, who receive stable cART, and who have sustained. Usual Adult Dose for Helicobacter pylori Infection.
In general, this drug effectively eradicates Streptococcus pyogenes from the nasopharynx; efficacy in the subsequent prevention of rheumatic fever has not been established. Pediatr Infect Dis. 10, gastrointestinal (GI) effects, general (13) 1-10, abnormal taste (adults, 3-7 diarrhea (3-6). Cross JT, Jacobs. Individual efficacy of clarithromycin (A-56268) and its major human metabolite 14-hydroxy clarithromycin (A-62671) in experimental pneumococcal pneumonia in the mouse. Swallow extended-release tablets whole; do not chew, break, or crush.
Clarithromycin (Biaxin) for Sinusitis, Pneumonia
Hardy RD, Rios AM, Chavez-Bueno S,. Addition of a third or fourth agent should be considered for patients with CD4 count less than 50 cells/mm3, high mycobacterial loads, or when effective ART is absent; some experts recommend rifabutin as a third agent. Jain R, Danziger. Am J Respir Crit Care Med. Ear and labyrinth disorders: Deafness was reported chiefly in elderly women and was usually reversible. Consult warnings section for additional precautions.
Fonseca-Aten M, Salvatore CM, Mejas A,. Primary MAC prophylaxis should be discontinued in patients responding to antiretroviral therapy (ART) with increase in CD4 count to greater than 100 cells/mm3 for at least 3 months; should restart if CD4 count declines to less than 50 cells/mm3. Usual Pediatric Dose for Pertussis Prophylaxis US CDC recommendations : Immediate-release : 1 month or older:.5 mg/kg orally every 12 hours for 7 days Maximum dose: 500 mg/dose Comments : -Recommended for treatment and postexposure prophylaxis -Macrolides are preferred. A comparative clinical study of macrolide-sensitive and macrolide-resistant Mycoplasma pneumoniae infections in pediatric patients. Treatment for...
Respiratory syncytial virus affects pulmonary function in balb/c mice. Usual Adult Dose for Skin and Structure Infection. Extended-release: 1000 mg orally every 24 hours for 14 days. Immediate-release : Triple therapy : -In combination with lansoprazole and amoxicillin: Clarithromycin 500 mg orally every 12 hours for 10 to 14 days -In combination with omeprazole and amoxicillin: Clarithromycin 500 mg orally every 12 hours for 10 days Dual.