Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Birth defects reported for more than 2 infants after first sleep Apnea Patients Who Are Drowsy During the Day at Risk for Heart Woes trimester exposure included ventricular septal defects (n 4) and pyloric stenosis (n 3). In healthy volunteers, the pharmacokinetics of butorphanol intranasal (1 mg) were not affected by the coadministration of a single dose of sumatriptan SC. Hydrocodone: (Major) Because of the potential risk and severity of serotonin syndrome, caution and careful monitoring are recommended when administering serotonin-receptor agonists with other drugs that have serotonergic properties such as opioids. Figure E Step. However, embryo-foetal viability might be porn, Partners, and Eating Disorders Pot for Agitation affected in the rabbit (see section.3).
Other reported clinical experience has not identified differences in responses between the elderly and younger patients. Data Human Data: The (sumatriptan and naproxen sodium) Pregnancy Registry, a population-based international prospective study, collected data for sumatriptan from January 1996 to September 2012. There are also reports in patients where no such predisposing factors are apparent. The pharmacokinetics of sumatriptan in patients with severe hepatic impairment have not been studied (see Section.3 Contraindications and Section.4 Warnings and Precautions). Visual disturbance Rare reports of transient and permanent blindness, including significant partial vision loss have been reported with the use of sumatriptan.
Racial Groups: The systemic clearance and Cmax of subcutaneous sumatriptan were similar in black (n 34) and Caucasian (n 38) healthy male subjects. Not known: Seizures, although some have occurred in patients with either a history of seizures or concurrent conditions predisposing to seizures. The onset of relief of migraine-associated symptoms is approximately 20 minutes. Undesirable effects may be more common during concomitant use of triptans and herbal preparations containing St John's Wort (Hypericum perforatum).Prolonged use of any type of painkiller for headaches can make them worse.
Imitrex Nasal Spray - FDA prescribing information, side
Dextromethorphan; Guaifenesin: (Moderate) Dextromethorphan inhibits serotonin reuptake and therefore should be used cautiously with serotonin-receptor agonists as serotonin syndrome may result. Trimipramine: (Moderate) Tricyclic antidepressants (TCAs) should be used cautiously with drugs that also augment serotonin, like the serotonin-receptor agonists triptans used for the treatment of migraine. Lactation Advise patients to notify their healthcare provider if they are breastfeeding or plan to breastfeed see Use in Specific Populations (.2 ). Selective serotonin reuptake inhibitors: (Major) Because of the potential risk and severity of serotonin syndrome, caution should be observed when administering selective serotonin reuptake inhibitors (ssris) with other drugs that have serotonergic properties such as serotonin-receptor agonists (e.g., sumatriptan). Used for acute treatment of migraine with or without aura and cluster headaches.
The developmental and health benefits of breastfeeding should be considered along with the mothers clinical need for Imitrex Nasal Spray and any potential adverse effects on the breastfed infant from sumatriptan or from the underlying maternal condition. Administration of sumatriptan should only be considered if the expected benefit to the mother is greater than any possible risk to the foetus. In 2 trials, a 5-mg dose was also evaluated. Other 5-HT1 Agonists Because their vasospastic effects may be additive, coadministration of Imitrex Nasal Spray and other 5-HT1 agonists (e.g., triptans) within 24 hours of each other is contraindicated. Pharmacodynamics Blood Pressure Significant elevation in blood pressure, including hypertensive crisis, has been reported in patients with and without a history of hypertension see Warnings and Precautions (.8 ). Trademarks are owned by or licensed to the GSK group of companies.
Sumatriptan bioavailability following intranasal administration is 17, similar to that after oral administration (15). HOW supplied, alsuma/Imitrex/Imitrex stat dose/Sumatriptan/Sumatriptan Succinate/Sumavel DosePro System/zembrace Subcutaneous Inj Sol:.5mL, 3mg, 4mg, 6mg. Do not store for later use. Therefore the use of sumatriptan is not recommended until further data are available. 6.5 Nature and contents of container The container consists of a type. Clinical Considerations Infant exposure to sumatriptan can be minimized by avoiding breastfeeding for 12 hours after treatment with Imitrex Nasal Spray.
Sumatriptan Nasal Spray - FDA prescribing information
Do not press the blue plunger yet. Only 3 of the dose is renally eliminated as unchanged drug, with 42 eliminated as the major metabolite. Sertraline: (Major) Because of the potential risk and severity of serotonin syndrome, caution should be observed when administering selective serotonin reuptake inhibitors (ssris) with other drugs that have serotonergic properties such as serotonin-receptor agonists (e.g., sumatriptan). Rx only 6 Nasal Spray Units Made in Spain 2017 GSK group of companies or licensor.
Once the medication has been delivered, discard the nosepiece. How to Use Imitrex Nasal Spray Provide patients instruction on the proper use of Imitrex Nasal Spray. Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine: (Major) Theoretically, concurrent use of methylene blue and serotonin-receptor agonists may increase the risk of serotonin syndrome. Infant exposure to sumatriptan can be minimized by avoiding breast-feeding for 12 hours after treatment.
The manufacturers of serotonin agonists contraindicate the administration of their drugs to patients receiving non-selective MAO inhibitors like linezolid or within 2 weeks of discontinuation of a MAO inhibitor. Linezolid: (Major) Linezolid is an antibiotic that is also a reversible, non-selective inhibitor of MAO and should not be administered with serotonin-receptor agonists. Relative bioavailabilities after the single dose were approximately 87 (90 CI, 82 to 94) and 58 (90 CI, 55 to 62) of those obtained after subcutaneous injections of 4 and 6 mg, respectively.63912 Nasal Powder Peak plasma concentration occurred. Imitrex can cause serious side effects, including: Heart attack and other heart problems.
Imitrex Intranasal, Onzetra Xsail (sumatriptan intranasal
Remove the Imitrex Nasal Spray unit from the plastic pack (see Figure A). Renal disease, renal failure, renal impairment Sumatriptan is renally excreted; therefore, renal impairment may contribute to an increase in bioavailability. Call your doctor for medical advice about side effects. This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome /toxicity. From this point on, do not touch the end of the medication chamber; keep chamber pointed away from face and eyes. Butorphanol: (Moderate) The safety of using intranasal butorphanol and sumatriptan nasal spray during the same episode of migraine has not been established; however, it should be noted that both products are capable of producing transient increases in blood pressure.
Hydrocodone; Potassium Guaiacolsulfonate: (Major) Because of the potential risk and severity of serotonin syndrome, caution and careful monitoring are recommended when administering serotonin-receptor agonists with other drugs that have serotonergic properties such as opioids. Conversely, it is advised to wait at least 6 hours following use of sumatriptan before administering an ergotamine-containing product and at least 24 hours before administering another triptan/5-HT1 receptor interaction may occur between sumatriptan and maois and concomitant administration is contraindicated (see section.3). However, as maprotiline primarily blocks norepinephrine uptake. Not known: Neck stiffness. The number of exposed pregnancy outcomes accumulated during the registry was insufficient to support definitive conclusions about overall malformation risk or for making comparisons of the frequencies of specific birth defects. Treatment for...
Dextromethorphan: (Moderate) Dextromethorphan inhibits serotonin reuptake and therefore should be used cautiously with serotonin-receptor agonists as serotonin syndrome may result. Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine: (Moderate) Dextromethorphan inhibits serotonin reuptake and therefore should be used cautiously with serotonin-receptor agonists as serotonin syndrome may result. For patients with risk factors predictive of CAD who are determined to have a satisfactory cardiac evaluation, the first dose of sumatriptan should be given in a controlled setting such as a clinic or physician's office. Hydrocodone; Pseudoephedrine: (Major) Because of the potential risk and severity of serotonin syndrome, caution and careful monitoring are recommended when administering serotonin-receptor agonists with other drugs that have serotonergic properties such as opioids. Gastrointestinal: Abdominal discomfort, diarrhea, dysphagia, gerd, dry mouth, thirst.