Lab-Grown Insulin-Producing Cells Pot and Sperm Insulin Pill?



Scientists successfully transformed human stem cells into insulin-producing cells that appeared to function normally when transplanted into mice. "This is a critical step towards our goal of creating cells that could be transplanted into patients with diabetes," said Matthias Hebrok, PhD, of the UCSF Diabetes Center, in a statement. (Nature Cell Biology)

More evidence was published this week affirming the high success rate of Roux-en-Y gastric bypass for putting type 2 diabetes into remission. (Diabetologia)

Compared with men who've never smoked, those who self-reported ever smoking marijuana had significantly higher sperm counts -- with no difference in said count in past versus current smokers. (Human Reproduction)

Rates of 12 obesity-related cancers in U.S. adults younger than 50 have increased since 1995. (The Lancet Public Health)

Spring-loaded pills that could enable oral delivery of large-molecule drugs such as insulin were tested successfully in pigs, MIT researchers said. (Science)

A protein known as clusterin -- expression of which is heightened with a Western diet -- was tied to components of metabolic syndrome, including insulin resistance and cardiovascular disease. (Diabetes Care)

Thyroid nodules were significantly more common in kids with extremely high insulin resistance, but treatment with recombinant leptin did appear to be responsible. (The Journal of Clinical Endocrinology & Metabolism)

Mount Sinai Health System, along with the World Professional Association for Transgender Health and the American Society of Gender Surgeons, will host their second annual gender-affirming surgery training Feb. 28 to March 2, featuring five live surgeries.

Source: https://www.medpagetoday.com/endocrinology/generalendocrinology/77901

A Person Can Be Their Own Donor Cells For Insulin



High blood sugar levels can damage blood vessels and nerves, predisposing the patient to a higher risk of blindness, heart disease, stroke, nerve disease, and limb amputations. Secondary Source, the Lancet, source Reference: Johnston KC, Durkalski-Mauldin VL "Considering prehospital stroke trials: Did right-2 get how a Heart Patient With AFib Was Saved by a Vest it right?" Lancet 2019; DOI:.1016/S0140-6736(19)30276-4. Layers of pancreatic cells were then grafted onto diabetic mice, where they produced enough insulin to control blood sugar levels for a week. Among secondary outcomes, the intervention was how to Have a Healthier Heart Just by Breathing worse in patients with intracerebral hemorrhage (. They were randomized to a nitroglycerin patch or a sham patch within 4 hours of symptom onset. The new Antibiotic, Omadacycline, Treats Pneumonia, Skin Infections Boston team was able to grow 35,000 islet cells from the duct cell precursors of one pancreas, which falls far short of a normal healthy pancreas that contains about one million islet cells. Treatment for...

Doctors have had some success with pancreas transplants, and with transplants of just the pancreatic beta cells (also known as islet cells). Without this additional insulin, people with type 1 diabetes could not survive. Fast-MAG had avoided the stroke mimic problem (only 4 in that trial) through use of telemedicine consultation in the ambulance. So, transplants require immune-suppressing medications. If large-scale trials show it to be safe and effective, the transplant technique could be in widespread us in as little as five years.