Low-Dose Tx Wins in Older Gastroesophageal Ca Patients



CHICAGO -- A reduced-dose palliative regimen for older and mostly frail patients with advanced gastroesophageal cancer yielded similar survival to a standard regimen, but with lower rates of high-grade toxicity and better quality of life, a randomized trial found.

Among the group of patients -- more than half of whom were considered very frail -- the lowest dose of oxaliplatin and capecitabine (Xeloda) was found to be non-inferior to standard treatment (HR 1.10, CI 0.90-1.33) and produced less toxicity, reported Peter S. Hall, PhD, of the University of Edinburgh in Scotland.

"Low-dose treatments may be offered to patients who are suitable for chemotherapy, but considered either too frail or too elderly for a full-dose standard regime, in the confidence that it can produce superior outcomes without compromising cancer control or survival," he said during a press briefing ahead of the American Society of Clinical Oncology (ASCO) meeting here.

From 2014 to 2017, the phase III GO2 trial randomized 514 patients with advanced gastric or esophageal cancers 1:1:1 to one of three treatment arms:

  • 130 mg/m2 oxaliplatin every 21 days plus 625 mg/m2 capecitabine twice daily (Level A)
  • Level A regimen but at 80% the dosage (Level B)
  • Level A regimen but at 60% the dosage (Level C)

Compared with the full-dose regimen, progression-free survival was found to be non-inferior in the two reduced-dose groups: 4.9 months (Level A) versus 4.1 months (Level B) and 4.3 months (Level C). Overall survival was comparable between the three groups: 7.5 months versus 6.7 and 7.6 months, respectively. Rates of grade 3 or higher toxicity occurred in 56% of the Level A and B groups and in 36% of the Level C group.

"One of the things that all oncologists who treat adults struggle with is a lack of data on elderly patients -- 60% of the patients we treat are elderly, but unfortunately only 10% of our clinical trials data comes from patients who are elderly," said ASCO President Monica M. Bertagnolli, MD, during the briefing. "It is wonderful to have real data to help guide their treatment."

The researchers also examined the secondary endpoint of overall treatment utility at 9 weeks, which takes into account six different domains: cancer progression, severe toxicity, global quality of life, oncologist's assessment of clinical benefit, as well as a patient score that the treatment was worthwhile and not interfering with daily activities.

"Patients on dose Level C had a better overall treatment utility compared to patients either on Level A or Level B, and this was due to lower side effects and better quality of life in those patients presumably," said Hall.

In the lowest-dose group, 43% of patients had good overall treatment utility compared with 35% in the full-dose group.

"This is the kind of data that oncologists get excited about -- being able to give more tolerable treatments with comparable outcomes," Nicholas Rohs, MD, of Tisch Cancer Institute at Mount Sinai in New York City, who was not involved with the research, told MedPage Today in an email. "To know that we can reduce doses, without sacrificing benefit, will allow me to give this therapy to more patients than before." Rohs added that the combination regimen is commonly used in his clinic.

A previous trial in a similar population found the three-drug combination of oxaliplatin, capecitabine, and epirubicin (Ellence) to be too toxic. The current study aimed to further improve the palliative treatment tolerability for these patients.

Median patient age in the study was 76 years (range 51 to 96). Those with decreased kidney function received 75% of the capecitabine doses. Roughly one-third (31%) of patients in each arm had an ECOG performance status ≥2. Most patients were considered frail (86%, 82%, and 76% in Levels A, B, and C, respectively) with a majority considered very frail (61%, 56%, 58%, respectively). Eligibility criteria included those fit enough for chemotherapy, but unfit for the three-drug regimen.

Hall noted that this is the largest randomized controlled trial to date specifically investigating frail or elderly patients with advanced gastric and esophageal cancers.

Hall reported relationships with Roche, Pfizer, Eisai, Novartis, AstraZeneca, and Daiichi Sankyo.

Radiotherapy Alone or Concurrent Chemoradiation for

celia fremlin

Salvage esophagectomy after failed definitive chemoradiation for esophageal adenocarcinoma. In this trial, 73 patients with localized (stage I-III) esophageal cancer received paclitaxel, Paraplatin and fluorouracil chemotherapy with radiation therapy before surgery. Strategies to Improve Treatment. Outcome of esophagectomy for cancer in elderly patients. The development of more effective cancer treatments requires that new and innovative therapies be evaluated with cancer patients. Treatment for...

To ensure that you are receiving the tadalafil vs cialis electric optimal treatment of your cancer, it is important to stay informed and follow the cancer news in order to learn about new treatments and the results of clinical trials. Unfortunately, cialis india xxxi a higher death rate following surgery has also been reported, which may cancel out any benefit from control of cancer by this more intensive treatment approach. Van Hagen P, Hulshof mccm, van Lanschot JJB,. Safety and efficacy of radiation and chemoradiation in patients over 70 years old with inoperable esophageal squamous cell carcinoma. Coia LR, Minsky BD, Berkey BA,.