New drug may stop sepsis from reaching major organs



Researchers discover a drug that has the potential to stop sepsis before the condition reaches major organs and becomes fatal.

A new preclinical trial of a sepsis drug brings hopeful results.

Sepsis is a life-threatening condition that occurs when an existing infection — such as one that develops in a cut, a respiratory infection, or a urinary tract infection — triggers an immune response that affects the body's tissues and major organs.

Sepsis constitutes a medical emergency because, if a person does not receive treatment, it can lead to death.

In the United States, over 1 million people experience severe sepsis every year, and up to 30 percent of these individuals die as a result.

Worldwide, over 30 million people have sepsis each year, and up to 6 million people die from it. Most commonly, sepsis is caused by Staphylococcus aureus and Escherichia coli.

New research brings much-needed hope for the treatment of sepsis. Researchers at the Royal College of Surgeons in Ireland (RCSI) — which is located in Dublin — have tested a compound called cilengitide in a preclinical trial. The drug goes by the brand name InnovoSep.

Steve Kerrigan, Ph.D., an associate professor in pharmacology at the RCSI, invented the drug and led the trial. Sinéad Hurley, a postdoctoral fellow at the RCSI's School of Pharmacy and Irish Centre for Vascular Biology, presented the findings at the RCSI Research Day 2019.

Prof. Kerrigan explains the need for such a drug, saying, "Sepsis occurs when an infection gets into the bloodstream and our own body's defense system spins out of control trying to fight the infection, which results in multiple organ failure, if untreated."

"There is only a short window of opportunity for treatment of sepsis, with the early administration of antibiotics and fluid. However, in many cases, antibiotics are not effective, due to drug resistance or delays in identifying the type of bacteria that has caused the infection," he continues.

"Therefore, there is a need for a nonantibiotic therapy that can be used at all stages of infection against all bacterial causes of sepsis," Prof. Kerrigan explains.

In the preclinical trial, the researchers successfully used InnovoSep to inhibit S. aureus and E. coli from binding to human endothelial cells, both in vivo and in vitro. Endothelial cells are "the first barrier between the blood and the extravascular space."

InnovoSep stopped the infection from advancing to septic shock and organ failure by preventing damage to endothelial cells.

This action, the authors note, prevents "thrombus formation, coagulation activation, inflammation, and loss of barrier integrity," which are the main processes that drive organ failure and death in sepsis.

In simpler terms, "The drug appears to act by preventing the bacteria from getting into the bloodstream from the site of infection by stabilizing the blood vessels so that they cannot leak bacteria and infect the major organs," notes Prof. Kerrigan.

"Our research has shown the InnovoSep candidate drug can prevent sepsis progression early or, indeed, treat advanced sepsis."

Steve Kerrigan, Ph.D.

The compound is an antagonist of the "major endothelial cell integrin," alpha-v beta-3. This integrin is an adhesion molecule that mediates the adhesion of cells to the extracellular matrix.

Because InnovoSep doesn't rely on an antibiotic mechanism, it is not vulnerable to the various drug-resistant strains of bacteria.

"The promising results of the InnovoSep preclinical trial gives hope for a new, nonantibiotic treatment of this condition that could be effective in both the early and more advanced stages of sepsis," concludes Prof. Kerrigan.

Source: https://www.medicalnewstoday.com/articles/324652.php

Promising, new Drug, shows Potential to, stop



A version of how to tell if your baby has asthma this article appears in print on, on Page D1 of the New York edition with kratom-Related Poisonings Are Soaring, Study Finds the headline: Critics Demand Halt of a Sepsis Trial. But while most adults know they must seek care immediately for a heart attack or stroke, only about half know that sepsis requires urgent medical attention, according to a survey by Sepsis Alliance, a nonprofit organization. They should also be monitored for signs of an infection. Vaccinations, viral infections, such as influenza (the flu chicken pox, and HIV, are caused by viruses. Nsaids are tested to treat how Best to Monitor Critically Ill Patients? sepsis in humans. Vasopressors can be administered early on, during or after the infusion of fluids; a new treatment guideline for hospitals says the drugs should be started within the first hour why sleep is good for your arteries if patients arent responding to intravenous fluids. Treatment for...

This involves frequently washing your hands to reduce the spread of bacteria, viruses, and fungi, explains. Finish the full course (7 days, 10 days, etc. In the days before sterile instruments and antibiotics, sepsis was a frequent and deadly complication of wounds. The trial protocol, he noted, was developed by more than 20 experts in emergency and critical care medicine, reviewed by an independent peer review committee and approved by a central institutional review board tasked with protecting the rights of human subjects. When patients experience septic shock, current guidelines call for raising blood pressure by administering fluids within the first three hours of care, and then administering vasopressors within the first six hours if patients do not respond to fluids. Because of this widespread problem, more and more antibiotics are becoming less effective against stopping infections.