Warnings Precautions warnings Serotonin syndrome (SS which is potentially life-threatening, has been reported with metaxalone use. Seek emergency medical attention or call the what can cause a sensitive breast? Poison Help line. Clinical Pharmacology clinical pharmacology Mechanism Of Action The mechanism of action of metaxalone in humans has not been established, but may be due to general central nervous system depression. Stop using Skelaxin and call your doctor at once if you have: weak or shallow breathing; a light-headed feeling, like you might pass out; pale or yellowed skin, dark colored urine, fever, confusion or weakness; or upper stomach pain.
What happens if I miss a dose? Table 1: Mean (CV) Metaxalone Pharmacokinetic Parameters Dose (mg) Cmax (ng/mL) Tmax (h) AUC (ngh/mL) t(h) CL/F (L/h) (53).3 (35) 7479 (51).0 (53) 68 (50) (43).0 (39) 15044 (46).0 (58) 66 (51) 1Subjects received 1x400 mg tablet. Taking Skelaxin with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties.
Skelaxin (metaxalone) is a muscle relaxant. Hepatic/Renal Insufficiency The impact of hepatic and renal disease on the pharmacokinetics of metaxalone has not been determined. Treatment Gastric lavage and supportive therapy. Common Skelaxin side effects may include: dizziness, drowsiness; nausea, vomiting, upset stomach; headache; or feeling nervous or irritable; This is not a complete list of side effects and others may occur. Skelaxin is only part of a complete treatment program that may also include rest, physical therapy, or other pain relief measures. Thereafter, metaxalone concentrations decline log-linearly with a terminal half-life.0.8 hours.
Skelaxin 400 mg tablet Drug encyclopedia Kaiser Permanente
How should I take Skelaxin? Skelaxin is not approved for use by anyone younger than 12 years old. From Back Pain Resources Featured Centers Health Solutions From Our Sponsors Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA. A glucose-specific test will differentiate findings. Overdosage Contraindications overdose Deaths by deliberate or accidental overdose have occurred with metaxalone, particularly in combination with antidepressants, and have been reported with this class of drug in combination with alcohol. Pharmacokinetics The pharmacokinetics of metaxalone have been evaluated in healthy adult volunteers after single dose administration of skelaxin under fasted and fed conditions at doses stelara vs. Humira: What’s the difference? ranging from 400 mg to 800.
Visit the FDA MedWatch website or call 1-800-FDA-1088. To make sure Skelaxin is safe for you, tell your doctor if you have liver or kidney disease. Take Skelaxin exactly as it was prescribed for you. Skelaxin can cause side effects that may impair your thinking or reactions. Dangerous side effects or death can occur when alcohol is combined with Skelaxin. False-positive Benedict's tests, due to an unknown reducing substance, have been noted.
The risk or severity of serotonin syndrome can be increased when Metaxalone is combined with 7-Nitroindazole, the risk or severity of adverse effects can be increased when Metaxalone is combined with 7-Nitroindazole. Do not drink alcohol. The mean half-life was.1 hours in females and.6 hours in males. The bioavailability of metaxalone was significantly higher in females compared to males as evidenced by Cmax (2115 ng/mL versus 1335 ng/mL) and AUC (17884 ngh/mL versus 10328 ngh/mL). Generic Name: metaxalone (me TAX a lone brand Names: Skelaxin, medically reviewed by, sanjai Sinha,.
Skelaxin (Metaxalone Side Effects, Interactions, Warning, Dosage
You may report side effects to FDA at 1-800-FDA-1088. It is not known whether metaxalone passes into breast milk or if it could harm a nursing baby. Store at room temperature away from moisture and heat. Be careful if you drive or do anything that requires you to be awake and alert. Before taking this medicine, you should not use Skelaxin if you are allergic to metaxalone, or if you have: anemia (low red blood cells severe kidney disease; or severe liver disease. Serial liver function studies should be performed in these patients.
In dogs, no LD50 could be determined as the higher doses produced an emetic action in 15 to 30 minutes. What other drugs will affect Skelaxin? Further information Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Skelaxin only for the indication prescribed. Contraindications Known hypersensitivity to any components of this product.
In a second food effect study of similar design, two 400 mg skelaxin tablets (800 mg) were administered to healthy volunteers (N59, 37 males, 22 females ranging in age from 18-50 years (mean age.6.7 years). You may need a dose adjustment or special tests to safely take Skelaxin. Metaxalone is metabolized by the liver and excreted in the urine as unidentified metabolites. Hepatic Cytochrome P450 enzymes play a role in the metabolism of metaxalone. Call your doctor for medical advice about side effects.
Skelaxin: Uses, Dosage Side Effects
Copyright Cerner Multum, Inc. Pregnancy Reproduction studies in rats have not revealed evidence of impaired fertility or harm to the fetus due to metaxalone. You should not use Skelaxin if you have anemia (low red blood cells or severe kidney or liver disease. Serotonin syndrome has been reported when metaxalone was used at doses higher than the recommended dose (see warnings ). Store at Controlled Room Temperature, between 15C and 30C (59F and 86F). Usual Pediatric Dose for Muscle Spasm: 12 years: 800 mg orally 3 to 4 times a day.
Drug Description, find Lowest Prices on, skelaxin ( metaxalone ) Tablets. Side Effects Drug Interactions, sIDE effects, the most frequent reactions to metaxalone include: CNS: drowsiness, dizziness, headache, and nervousness or irritability; Digestive: nausea, vomiting, gastrointestinal upset. Medication Guide patient information skelaxin may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle, especially when used with alcohol or other CNS depressants. Drug interactions No information provided. Skelaxin is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures. Treatment for...
Metaxalone has no direct action on the contractile mechanism of striated muscle, the motor end plate, or the nerve fiber. The risk or severity of serotonin syndrome can be increased when Metaxalone is combined with Abacavir, metaxalone may decrease the excretion rate of Abacavir which could result in a higher serum level. NDC ) and in bottles of 500 (. Skelaxin may also be used for purposes not listed in this medication guide.