Are Scientists Closer to Growing Made-to-Order Kidneys?

A shortage of donor kidneys means many people with kidney failure never get a transplant. In the United States alone, 95,000 people are waiting for a new kidney.

To address shortages of donor organs, scientists are trying to find ways to grow healthy organs outside the human body.

One approach that's produced promising results is called blastocyst complementation. Blastocysts -- the clusters of cells formed several days after egg fertilization -- are taken from lab animals bred to lack specific organs.

The blastocysts are injected with stem cells from a normal animal, though not necessarily of the same species. The stem cells form the entire missing organ in the new animal. That organ can potentially be transplanted to another animal.

"We previously used blastocyst complementation to generate rat pancreas" in mice without a working pancreas, said study lead author Teppei Goto, a researcher at the National Institute for Physiological Sciences in Okazaki-shi, Japan.

"We therefore decided to investigate whether the method could be used to generate functional kidneys, which would have much greater application in regenerative medicine owing to the high donor demand," Goto said in an institute news release.

Researchers first tried to grow rat kidneys in mice but were unsuccessful. But they were able to grow mice kidneys in rats.

Corresponding author Masumi Hirabayashi, an associate professor at the institute, said the study confirms the method is viable for kidney generation.

"In the future, this approach could be used to generate human stem cell-derived organs in livestock, potentially extending the [human] life span and improving the quality of life of millions of people worldwide," Hirabayashi said.

The study was published Feb. 5 in the journal Nature Communications.

More information

The National Kidney Foundation has more on kidney transplant.


Beyond Dialysis: Researchers Are Making Implantable

The first time Roy saw Humes set-up, he immediately recognized its promiseand its limitations. Late last year, Organovo, a biotech company in San Diego, began distributing the first commercially available body-part printer. Fissell had convinced him to drive from Cleveland to Ann Arbor in the middle of a snowstorm to check it out. Peer-reviewed open access journals has also grown in modern learning environment as most of the students need a swift and instant access to published research work free of cost. Nick Stockton, scientists 3-D Print Mouse Ovaries That Actually Make Babies. Treatment for...

And 4,000 of them died. Every week, two million people across the world will aDT, Sex Top QOL Problems in Prostate Cancer sit for hours, hooked up to a whirring, blinking, blood-cleaning dialysis machine. At the time, the moral cost of failing to provide lifesaving care was deemed greater than the financial setback of doing. The new bladder is nurtured in an incubator that mimics body conditions, allowing the cells to grow and knit together. Yes, you read correctly: a printer for body parts. This led to treatment rationing and the arrival of death panels to the American consciousness.