HOW supplied Condylox Gel (podofilox gel).5 is supplied.5 g of clear gel in aluminum tubes with an applicator tip. Do not use it later for another skin problem unless directed by your doctor. Immediately after applying this medicine, wash your hands to remove any medicine. Pregnancy Pregnancy Category C:.5 podofilox solution was not teratogenic in the rabbit following topical application of up.21 mg/kg (2.85 mg/m2, approximately 2 times the maximum human dose) once daily for 13 days. Condylox, gel (podofilox gel).5.
If no improvement is observed after 4 weeks of treatment, discontinue the medication and consult the health care provider. Savel.: Clinical experience with intravenous podophyllotoxin. It is not known whether podofilox topical passes into breast milk or if it could harm a nursing baby. Drug interactions No information provided. There is no evidence to suggest that more frequent application will increase efficacy, but additional applications would be expected to increase the rate of local adverse reactions and systemic absorption. Before using this medication, tell your doctor about all prescription and nonprescription/herbal products you use.
J Cancer Inst 11:839-841, 1951. Podofilox was not mutagenic in the Ames plate reverse mutation assay at concentrations up to 5 mg/plate, with and without metabolic activation. The effect of podophyllotoxin on the skin of the mouse, with reference to carcinogenic, cocarcinogenic, and anticarcinogenic action. New warts or return of old warts may occur, especially in the first 3 months after treatment. Keep out of reach of children.
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This medicine may be harmful if swallowed. Impotence (ED) Slideshow Pictures, take the Quiz on STDs, indications. Avoid contact with the eyes. Induction of the deficient acid DNAase activity in mouse interfollicular epidermis by croton oil as a possible tumor promoting mechanism.
This medication is not a cure. Sex Trans Disease 1982: zyban yorum 9: 26-33. Clinical Studies In the first multicenter clinical study in 326 patients with anogenital warts, Condylox Gel (podofilox gel).5 and its vehicle were applied in a double-blind fashion to comparable patient groups. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
Impotence (ED) Slideshow Pictures, take the Quiz on STDs, dosage. Corona, CA 92880 USA by DPT Laboratories, Ltd. Patients applied Condylox Gel (podofilox gel).5 twice daily for three consecutive days followed by a 4 day "rest" period. Make sure the treated area is dry before allowing the treated skin to come in contact with normal, untreated skin. Do not share this medication with others. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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US residents can call their local poison control center. It is not intended to disclose all possible adverse or intended effects. Published animal studies, in general, have not shown the drug substance, podofilox, to be carcinogenic.2,3,4,5,6 There are published reports that, in mouse studies, crude podophyllin resin (containing podofilox) applied topically to the cervix produced changes resembling carcinoma. How to Take It, to apply the solution, use the applicators that come with the solution or a cotton-tipped applicator. Drug Description, find Lowest Prices on, condylox Gel.5 (podofilox) Gel.
Store at controlled room temperature between 15 - 30C (59 - 86 F). San Antonio, TX 78215. Precautions General Data are not available on the safe and effective use of this product for treatment cheap sildenafil zombie of warts occurring on mucous membranes of the genital area (including the urethra, rectum and vagina ). Patients should be advised not to use this medication for any disorder other than for which it was prescribed. Podophyllotoxin in serum: Absorption subsequent to three day repeated applications of.5 ethanolic preparation on condylomata acuminata. J Obst Gyn 14:1-10, 1959.
Kaminetzky HA, McGrew EA: Podophyllin and mouse cervix: Effect of long term application. This includes supplements and herbal products. Overdosage Contraindications overdose Topically applied podofilox may be absorbed systemically (see clinical pharmacology section). Keep Away From Open Flame.
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Podofilox topical is typically applied morning and evening for 3 days in a row, followed by 4 days off. In one reported experiment, epidermal carcinoma of the vagina and cervix was found in 1 out of 18 mice after 120 applications of podophyllin8 (the drug was applied twice weekly over a 15-month period). Diagnosis, although anogenital warts have a characteristic appearance, histopathologic confirmation should be obtained if there is any doubt of the diagnosis. Severe reactions were most frequent within the first 2 weeks of treatment. Otherwise, call a poison control center right away.
If contact with the eyes occurs, patients should immediately flush the eyes with copious quantities of water and seek medical advice. Am J Clin Path 35:538-545, 1961. If there is incomplete response after four treatment cycles, discontinue treatment and consider alternative treatment. Its chemical name is 5R,-(5, 5a, 8a, Podofilox has the following structural formula: Sexually Transmitted Diseases (STDs) Slideshow Pictures. The scientific literature contains references that podofilox is embryotoxic in rats when administered intraperitoneally at a dose of 5 mg/kg (29.5 mg/m2, approximately 19 times the recommended maximum human dose.)9 Teratogenicity and embryotoxicity have not been studied with intravaginal application. Treatment for...
This product is not indicated in the treatment of mucous membrane warts (see. Do not double doses or take extra medicine to make up for the missed dose. Carcinogenesis, Mutagenesis and Impairment of Fertility An 80-week carcinogenicity study in the mouse was performed using.5 podofilox solution applied dermally.04,.2 and.0 mg/kg/day. Clinical Pharmacology clinical pharmacology Mechanism of Action Treatment of anogenital warts with podofilox results in necrosis of visible wart tissue. Do not double the dose to catch. Kaminetzky HA, Swerdlow.