Prescription fish oil icosapent ethyl (Vascepa) was recommended for secondary prevention in diabetes in the American Diabetes Association's updated guidelines. (FiercePharma)
Amarin filed for that indication based on the REDUCE-IT trial, with a decision expected from the FDA by 2020. (Seeking Alpha) The company also announced priority review by Canadian regulators.
For omega-3 fatty acid combination products -- eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) -- at a dose of 1 g/day, the European Medicines Agency cautioned against use for secondary prevention in patients with a prior heart attack, calling it ineffective. "This means that these medicines should no longer be used in this way. However, they can still be used to reduce levels of ... triglycerides."
For preeclampsia, a rapid "red dye on paper" urine test outperformed measured serum and urine markers in a prospective study. (E-Clinical Medicine)
The fastest rising salaries in medicine are in cardiothoracic surgery. (Cardiovascular Business)
GLP-1 receptor agonist drugs that reduce heart risk in type 2 diabetes have seen little uptake by cardiologists. (Journal of the American College of Cardiology)
The first stroke rehabilitation trial for infants is getting underway. (Virginia Tech Daily)
The FDA cleared the CardioFlux Magnetocardiograph device for non-invasive, rapid cardiac imaging and Omron's Complete, a wearable device that combines blood pressure monitoring and EKG. (FDAnews)
The third-generation HeartLight X3 endoscopic laser ablation system was cleared for use in Europe. (Mass Device)
Bystander CPR nearly doubled over the past 18 years in Sweden, researchers reported in Circulation.
In Japan, women are less likely to get bystander CPR than are men. (Mayo Clinic Proceedings)
Fat metabolism in the heart may be tied to heart failure. (Circulation)
Only a handful of states have policies requiring paramedics to take stroke patients straight to a thrombectomy-capable hospital if feasible in time, but just getting all stroke patients to call an ambulance is a bigger hurdle to care. (PEW Trusts Stateline)
A computer model appeared to predict which arrhythmogenic right ventricular cardiomyopathy patients would benefit from primary prevention implantable cardioverter defibrillators better than the standard consensus-based algorithm. (European Heart Journal)
Just how much healthcare spending is racked up due to people sitting too much was detailed in a British study. (Journal of Epidemiology and Community Health)
Fish oil vs Vascepa
The fewer Complications With Robotic Surgery in Endometrial Cancer absorption of dietary fats is a complicated process that requires many steps including the transport of fat from the diet into the intestine cell, and then from the intestine cell to the lymphatic system and then to the blood. The free fatty acids are then taken up by the cells of the small intestine but must then be reconverted to TGs in order to form chylomicrons, then leave the cell, enter the lymphatic system and then the blood. Chylomicrons enable fats to move within the water-based solution of the bloodstream, allowing the TGs to be transported out of the cells of the small intestine through the lymphatic system (a transport network of clear fluid called lymph). Simply put, EPA and DHA have to compete with other fatty acids, including omega-6 fats, for this tick Bites More Likely to Cause Red Meat Allergy Than Thought space. It is likely the mechanism of action of fish oil is similar to that of aspirin in that they both favorably optimize prostaglandin production. Methods: Primary outcomes: fatal CHD nonfatal heart attacks stroke major vascular events all-cause mortality Inclusion Criteria: Must be a randomized controlled trial Studies must have a minimum of 500 participants Studies must be at least one year long Studies must. Treatment for...
The FDA has approved a new prescription formulation of fish oils for the treatment of very high levels of triglycerides. In the small intestine, it is again the pancreatic enzyme lipase that breaks the fatty acids from the ethanol backbone; the fatty acid-ethanol bond is more resistant to lipase compared to TGs, therefore slowing this process, and producing free fatty acids plus ethanol. Unlike lower neoadjuvant Anti-PD-1 Predicts Melanoma Outcomes concentration standard fish oil supplements, Igennus 70-90 EE and rTG supplements enable therapeutic blood plasma levels of omega-3 to be achieved. Ironically, taking too much fish oil can actually increase the risk of stroke. Phospholipids are comprised of two fatty acids joined to a phosphate group (such as choline) and a glycerol molecule. 2003 Apr 2;289(13 1667-74.