Are pregnant or plan to become pregnant. Anaphylactic/Anaphylactoid Reactions Anaphylactic/anaphylactoid reactions have occurred in patients receiving imitrex. Sumatriptan Nasal Spray, USP is not recommended for use in patients younger than 18 years of age. With your other hand, hold the container with your thumb supporting the container at the bottom, and your index and middle fingers on either side of the nozzle (see Figure D).
Imitrex, nasal, spray ( sumatriptan ) is indicated for the acute treatment of migraine attacks with or without aura in adults. Imitrex Nasal Spray passes into breast milk and may harm a nursing baby. You should write down when you have headaches and when you use Sumatriptan Nasal Spray, USP so you can talk with your healthcare provider about how Sumatriptan Nasal Spray, USP is working for you. Caution patients to avoid spraying the contents of the device in their eyes. At the same time, press the plunger firmly with your thumb.
If you do not get any relief after your first nasal spray, do not use a second nasal spray without first talking with your healthcare provider. See also: Emgality, sumatriptan Nasal Spray, USP is indicated for the acute treatment of migraine with or without aura in adults. The osmolality of the solution is 372 or 742 mOsmol for the 5- and 20-mg Imitrex Nasal Spray, respectively. If the migraine has not resolved by 2 hours after taking Sumatriptan Nasal Spray, USP, or returns after a transient improvement, 1 additional dose may be administered at least 2 hours after the first dose. What are the possible side effects of Sumatriptan Nasal Spray, USP? When administered by the intravenous route to pregnant rabbits, sumatriptan was embryolethal (see Data ).
Imitrex nasal spray - gsksource
In a trial of 14 healthy females, pretreatment with an MAO-A inhibitor decreased the clearance of subcutaneous sumatriptan, resulting in a 2-fold increase in the area under the sumatriptan plasma concentration-time curve (AUC corresponding to a 40 increase in elimination halflife. The occurrence of major birth defects (excluding fetal deaths and induced abortions without reported defects and all spontaneous pregnancy losses) during first-trimester exposure to sumatriptan was.2 (20/478 95 CI:.6.5) and during any trimester. Adverse Reactions Reported by at Least 1 of Patients and at a Greater Frequency than Placebo in Controlled Migraine Clinical Trials Adverse Reaction Percent of Patients Reporting imitrex health Highlights: March 15, 2019 Nasal Spray 5 mg (n 496) imitrex Nasal Spray 10 mg (n 1,007) imitrex Nasal Spray 20 mg. Concomitant Use with Other Triptans or Ergot Medications Inform patients that use of Sumatriptan Nasal Spray, USP within 24 hours of another triptan or an ergot-type medication (including dihydroergotamine or methysergide) is contraindicated see Contraindications ( 4 Drug Interactions (.1,.3 ).
The highest oral and intravenous no-effect doses for developmental toxicity in rabbits were 15 and.75 mg/kg/day, respectively. The recommended adult dose of Sumatriptan Nasal Spray, USP for the acute treatment of migraine is 5 mg, 10 mg, or. D Data are for attack 1 only of multi-attack trial for comparison. USE IN specific populations Pregnancy Risk Summary Data from a prospective pregnancy exposure registry and epidemiological studies of pregnant women have not detected an increased frequency of birth defects or a consistent pattern of birth defects among women exposed to sumatriptan. The plunger may feel stiff and you may hear a click.
Store your medicine away from light. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. Other 5-HT1 college Bribery Scandal Snags Doc Genitals on Instagram Smollett EHR Snooping Agonists Because their vasospastic effects may be additive, coadministration of Sumatriptan Nasal Spray, USP and other 5-HT1 agonists (e.g., triptans) within 24 hours of each other is contraindicated. The trials did not establish the efficacy of Imitrex Nasal Spray compared with placebo in the treatment of migraine in adolescents.
Sumatriptan Nasal Spray
01/2018 principal display panel 5 mg Front Container Label Sumatriptan Nasal Spray, USP 5 mg NDC principal display panel 5 mg Back Container Label Manufactured for: Lannett 039Mentally Tiring039 Jobs May Up Women039s T2D Risk Company, Inc. The pharmacokinetics of sumatriptan in patients with severe hepatic impairment has not been studied. Geriatric Use Clinical trials of Imitrex Nasal Spray did not include sufficient numbers of patients aged 65 and older to determine whether they respond differently from younger patients. Arrhythmias Life-threatening disturbances of cardiac rhythm, including ventricular tachycardia and ventricular fibrillation leading to death, have been reported within a few hours following the administration of 5-HT1 agonists. Estimated Probability of Achieving Initial Headache Response within 120 Minutesa a The figure shows the probability over time of obtaining headache response (no or mild pain) following treatment with intranasal sumatriptan.
Safety and effectiveness of Sumatriptan Nasal Spray, USP have not been established for cluster headache. Call your doctor if you have any unusual problems while taking this medication. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Some have occurred in patients with either a history of seizures or concurrent conditions predisposing to seizures.
If your symptoms improve after you use sumatriptan but return after 2 hours or longer, you may use a second dose of sumatriptan. Before treating headaches in patients not previously diagnosed as migraineurs, and in migraineurs who present with atypical symptoms, exclude other potentially serious neurological conditions. Related questions Medical Disclaimer Next Tips Add to My Med List. If you use too much Sumatriptan Nasal Spray, USP, call your healthcare provider or go to the nearest hospital emergency room right away. Seizures have happened in people taking imitrex who have never had seizures before.
Imitrex Nasal Spray
It is usually used at the first sign of a migraine headache. The highest no-effect dose was 50 mg/kg/day. Serious side effects of Imitrex Nasal Spray include: Tell burden of Autism in Teens Weighs Heaviest on Minorities, Poor your doctor right away if you have any serious side effects of Imitrex Nasal Spray including: blue fingers/toes/nails, cold hands or feet, hearing changes, or mental/mood changes. (002277481) Establishment Name Address ID/FEI Operations Lannett Company, Inc. There have been rare reports of serious cardiac adverse reactions, including acute myocardial infarction, occurring within a few hours following administration of Sumatriptan Nasal Spray, USP. MAO inhibitors interaction studies have not been performed with intranasal sumatriptan.
If you use too much imitrex, call your healthcare provider or go to the nearest hospital emergency room right away. Stop taking Sumatriptan Nasal Spray, USP and get emergency medical help right away if you have any of the following symptoms of a heart attack: discomfort in the center of your chest that lasts for more than. Earlier examinations for these toxicities were not conducted and no-effect doses were not established. Elimination The elimination half-life of sumatriptan administered as a nasal spray is approximately 2 hours, similar to the half-life seen after subcutaneous injection. It may harm them. This is not a complete list of side effects and others may occur. Treatment for...
How should I store Sumatriptan Nasal Spray, USP? Intranasal sumatriptan has not been evaluated for age differences. Contraindications, sumatriptan Nasal Spray, USP is contraindicated in patients with: Ischemic coronary artery disease (CAD) (angina pectoris, history of myocardial infarction, or documented silent ischemia) or coronary artery vasospasm, including Prinzmetals angina see Warnings and Precautions (.1 wolff-Parkinson-White syndrome. The frequency and time to use of these additional treatments were also determined. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Serotonin Syndrome Caution patients about the risk of serotonin syndrome with the use of Imitrex Nasal Spray or other triptans, particularly during combined use with ssris, snris, TCAs, and MAO inhibitors see Warnings and Precautions (.7 Drug Interactions (.4 ).